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How CBD works with the body
In order to fully understand how ANY benefits of CBD may be felt by the body and to subsequently decide what dosage is required, it helps to have an understanding of how cannabidiol interacts and affects different areas.
Cannabidiol & the bloodstream
Once in the bloodstream, CBD can interact with the cells of your body in many ways. More specifically CBD can interact with a network of receptors called cannabinoid receptors that sit on the surface of your cells. These receptors are present in your brain, spinal cord, on your skin and muscle cells as well as throughout your organs. They make up a whole network or system, called the endocannabinoid system.
The receptors of the endocannabinoid system have different shapes and sizes which respond to different cannabinoids from the cannabis plant in different ways. Out of these different shapes and sizes, there are two prominent types, called CB1 and CB2.
CB1 receptors exist primarily within the central nervous system, so within the brain and spinal cord and in the adipose tissue and many visceral organs, including most endocrine organs.
CB2 receptors exist primarily outside of the central nervous system, positioned in the peripheral nervous system (peripheral nerve endings) and on the surface of the immune system cells.
These compounds are primarily found in the plant type cannabis sativa. While cannabis sativa has been associated with marijuana and the psychoactive compound THC, only some parts of the plant contain noteworthy amounts of THC. Plant matter containing less than 0.2% THC is classified as hemp and known to be largely non-psychoactive.
Puregenics CBD is formulated from the Cannabis Sativa L plant (Hemp) The THC content has been removed.
As with any natural product, it is important to speak with your physician/doctor/medical team prior to beginning use.
There are some slight risks associated with using CBD in high doses or for extended periods of time including: mild low blood pressure, dry mouth, light-headedness, sedation, reduced activity of T and B cells, decreased fertilization capacity, reduced p-glycoprotein activity, reduced activity of the cytochrome P450 (CYP450) enzyme.
Please keep in mind that these side effects illustrate worst-case scenarios with CBD, and are not necessarily typical.
There is one major exception to the ‘generally harmless’ attribute about CBD and that is the negative effect cannabinoids can have on the functioning of the liver’s CYP450 enzyme.
Approximately 60% of all pharmaceutical drugs undergo metabolism by this enzyme, including: but not limited to:
Steroids, HMG CoA reductase inhibitors, calcium channel blockers, antihistamines, prokinetics, HIV-antivirals, immune modulators, benzodiazepines, antiarrhythmics, antibiotics, anaesthetics, antipsychotics, antidepressants, anti-epileptics, beta blockers, PPI’s, NSAID’s, angiotensin II blockers, oral hypoglycemic agents, sulfonylureas. It is important to note that even something as benign as grapefruit juice can cause the same CYP450 enzyme inhibitory action as CBD.
The most important thing to do before taking CBD (or any other herbal product) is to research any possible drug interactions and talk with your medical team to address any additional questions regarding CBD drug interactions or overdose concerns.
If you had an allergy to coconuts, coconut oil, medium chain trilycerides, or any other part of MCT oil (medium chain triglycerides). Please be aware that our CBD Oil contains MCT oil.
The Human Body
The human body is a complex machine, and the way it interacts with any compound, including cannabidiol (CBD) can be even more so. We’ve only known about the system in our body that cannabinoids are part of since the 1990’s so there is definitely so much more to learn! Nonetheless, here some of the basic science that is available at the moment: CBD (cannabidiol) is one of many (possibly between 60 and 140) compounds found in hemp. It’s the second most prevalent compound (second only to THC) in cannabis. Please note that CBD in the UK is manufactured from the hemp plant) CBD belongs to a class of molecules called phyto-cannabinoids and is non-psychoactive. This is the part of the plant that may keep you healthy (bold statement as medically not yet proven whatsoever). The endocannabinoid system (ECS), named after the plant that led to its discovery, is perhaps the most important physiologic system involved in establishing and maintaining human health. The endocannabinoid system (ECS) plays a very interesting and varied role within the body. At its most basic, the endocannabinoid system is a huge network of cannabinoid receptors which are spread throughout the body. The human endocannabinoid system releases cannabinoids that interact with receptors found in virtually all of the tissues in our bodies.
The role of the endocannabinoid system is to bring balance to our tissues, including the heart, digestive, endocrine, immune, nervous, and reproductive systems. In short, it’s working to keep you in neutral. Neutral means different things in different areas of your body, which is possibly one of the very best things about the compound – it can have a different impact on different receptors in your body. Cannabinoid receptors are found throughout the human body embedded in the cell membranes. When they’re activated, it can be by naturally occurring endocannabinoids. There are two major cannabinoid receptors – CB1 and CB2 ( researchers speculate there may be a third cannabinoid receptor waiting to be discovered). CB1 receptors are concentrated in the brain and central nervous system but also sparsely populated in other parts of our bodies. CB2 receptors are mostly in the peripheral organs especially cells associated with the immune system. How can one cannabinoid effect so many bodily processes without causing adverse side effects? The answer lies in our bio chemistry (the natural intelligence of the body). We have naturally occurring cannabinoid receptors all over our body that may interact with CBD. These receptors exist because our body is already making its own cannabinoids. The receptors and cannabinoids make up our endocannabinoid system. Our endocannabinoid system is always in action and is a major factor in keeping our bodies in a neutral state. Neutral may be different in our heads, hands, digestive systems, and so on. The brain contains a large number of highly specialized cells called neurons-these cells are connected by a multitude of gaps called synapses. This is how the cells communicate with one another.
These receptors are divided into two categories: CB1 which are located in the brain, central nervous system and many other parts of the body and CB2 which are found throughout the body in cells associated with our immune system. CB1 receptors are known to produce the psychoactive effect, maintenance of the body’s homeostasis while CB2 receptors are primarily involved in controlling the prominent features of the immune system. You may wonder how CBD, which is an external plant, finds a way to enter a human cell and create and bind so naturally. This is done by passing through a fatty acid protein which leads directly to the surface of the mitochondria, the power house of our cells. Once inside the cell, the plant based chemicals are broken down through metabolic enzymes and become a natural property of the micro organism.
The correct dosage can depend on the person
A major point about CBD oil is that its concentration varies at the preparation level. It can range from one milligram to hundreds of milligrams per dose.
PuregenicsCBD content ranges from 1000mg in our 10ml bottle to 9,000 mg in our 30ml bottles.
We now have a 3000mg in 30ml bottle, 6000mg in a 30ml bottle and our current highest strength of 9000mg in a 30ml bottle.
It is possible therefore that PuregenicsCBD may be a higher concentrate than the CBD product you are already using.
Quality matters more than quantity with CBD, hence it is important to have organic, third party laboratory tested, certified quality controlled, with a clear understanding of the strength of the CBD.
There is not one ‘right amount’ to take. Each person will react differently to different dosages depending on their current personal endocannabinoid system…… a bit vague granted but we have to be careful and monitoring your dosage is essential with the FSA recommending no more than 70mg per day.
It is worth remembering that there is still a lot about CBD that we don’t know. As the CBD industry grows, researchers are likely to conduct more studies on all cannabinoids.
The amount of CBD you should take depends on a range of factors, including your body weight, your body chemistry and the concentration of the CBD in each bottle.
There are a lot of variables that go into deciding how much CBD to take.
Before trying CBD, be sure to talk to your doctor about an appropriate dosage and any potential risks. If your doctor tells you how much to use, stick to their recommendation.
This is especially important if you’re taking a prescription medication that already contains CBD.
If your doctor doesn’t provide a recommendation, it’s best to start with a smaller dosage and gradually increase it. This could mean starting with 20mg to 40mg a day. After one week, increase this amount by 5mg until you reach a dosage that you feel happy with the daily amount you are consuming.
Not only does the method of administration determine the onset and duration of effects, but it can also influence the quantity of the dose you may need to take.
CBD has very low oral bio-availability, so CBD products ingested orally will lose a significant amount of the CBD through the digestive system, leaving only a part of it to enter it into the bloodstream and when applied topically to the skin, CBD also may not reach the bloodstream. Instead, it will interact with nearby cannabinoid receptors . Similar to oral ingestion, transdermal application typically requires a higher dose, in order to ensure it permeates the skin deep enough to reach those cannabinoid receptors.
Allowing CBD to enter the bloodstream directly, through the mucus membrane under the tongue allows a higher amount of CBD to be absorbed into your system.
It can be hard to figure out how much CBD is in one drop but our packaging specifies the total amount of CBD in the entire bottle.
One drop is about 0.05 millilitres (ml). That is one drop, not a full pipette-just a single drop. This means that our 30mg per 30ml bottle of CBD oil contains around 600 drops.
There are very few known side effects of CBD. If and when side effects do occur however, they may include diarrhea, appetite changes, low blood pressure, a dry mouth, nausea, fatigue and also possible changes in weight.
There are suggestions to base your CBD daily intake on your body weight.
It has been suggested to consume 1mg to 6mg per 4.5 kg of body weight, but everyone is different and it could depend on your metabolism, therefore starting slowly with a small intake of CBD per day is possibly the best way to consume CBD.
The way you consume CBD can affect the dosage
Some suggested ways to consume CBD
The sublingual method:
Possibly the most effective method for taking CBD oil is to put a drop or two under the tongue so that the mucus membranes in the mouth can absorb the CBD.
CBD oil under the tongue offers a faster delivery, because the CBD oil gets to bypass the digestive system and metabolization by the liver.
To take CBD oil drops, simply place your preferred number of drops under your tongue for 60-90 seconds to allow the natural chemicals to be absorbed.
Ingest Orally (Ingestion Method)
When you ingest CBD, it passes through the digestive system and is metabolized by the liver, eventually delivering its active compounds to your bloodstream, however up to 40% of the CBD is lost during this process and passed out of the body.
Absorption in the stomach may possibly be increased by consuming foods high in fat, it has been suggested that fatty acids found in foods can serve as carriers for cannabinoids like CBD, allowing them to move through the body for faster processing. Obviously this is a slower process and can take 2 to 3 hours for the CBD to be delivered into the blood stream.
When applied topically to the skin, CBD also won’t reach the bloodstream. Instead, it will interact with nearby cannabinoid receptors. Similar to oral ingestion, transdermal application typically requires a higher dose, in order to ensure it permeates the skin deep enough to reach those cannabinoid receptors.
Around 72,000 veins run through the area behind the belly button that are connected to various organs and tissues, such as
the stomach, large intestine, bladder, and the brain. Hence, by applying CBD oil to your belly button, it has been suggested that cannabinoids (CBD) can effectively be absorbed into the blood vessels and travel throughout the body in a quick and non- invasive way.
We are committed to using only the finest feminised hemp seeds with no pesticides, or genetic modification.
We are also proud to be members of Ifoam Organics International.
The THC percentage in the initial extraction is already below 0.2% as we use the finest European hemp as our seed plant.
The concentrated oil that we produce from our plants is then dispatched to our UK based retail company PuregenicsCBD UK Limited.
The concentrated CBD oil is then processed into the different strengths, then bottled and packaged to the highest standard in the UK. Our product is then despatched to our customers from our office in the UK, where we monitor every step of the process. Each product has a batch code number and a record is kept for each sale of that specific batch code production.
We are committed to using only the finest feminised hemp seeds with no pesticides nor genetic modification. Our CBD products are totally organic and are grown on our own farm in Southern Spain (Andalucia).
Due to this we can have at times have possible situations where we may be out of stock of certain strengths of our CBD, as we could be awaiting new production from the latest crop of our hemp plants.
Hemp is a rather adaptive plant, and it will survive in different climates without the need for herbicides and pesticides. Our hemp plants are grown on our own farm with the highest standard and care from seed to plant to CBD extract companies with their products and services that meet pre-determined standards are given ISO laboratory certifications.
CBD is short for Cannabidiol, which is one of the hundreds of cannabinoid compounds present in the cannabis plant. Unlike THC (Tetrahydrocannabinol) however, this compound does not make people ‘high’.
While CBD should not be used as a medicine, it does have several properties that may be beneficial.
CBD will not prevent you from suffering from diseases, nor will it cure you.
However, it is 100% safe to consume, without the unwanted side effects in the majority of cases, but every one is different and in can very rarely cause some very minor side effects, if this happens stop using CBD for about 7 days and then try starting again with a smaller dose.
Organically-grown hemp is key to the most excellent CBD oils.
PuregenicsCBD Full spectrum CBD oil has all the cannabinoids cbda, cbdv, cbg, cbga, cba, cbca, cbn, cbna.